Stem Cell Injections for Poor Ovarian Response in IVF

One of the most challenging obstacles in fertility treatment is poor ovarian response—when the ovaries produce fewer eggs than expected during an IVF cycle. This condition often limits the success of traditional treatments, especially for women of advanced reproductive age or those with diminished ovarian reserve. However, recent advances in regenerative medicine have introduced a promising solution: stem cell injections. These innovative therapies aim to rejuvenate ovarian tissue, improve follicle development, and enhance the chances of producing high-quality eggs. As clinical studies continue to explore the safety and efficacy of this groundbreaking approach, many patients are now considering stem cell therapy as part of their IVF journey. In this blog, we’ll examine how stem cell injections work, who may benefit most, and what the future holds for ovarian regeneration in reproductive medicine.

Types of Stem Cells Used: MSC vs SVF

In ovarian rejuvenation therapy, two main types of stem cells are commonly explored: mesenchymal stem cells (MSCs) and stromal vascular fraction (SVF). MSCs are multipotent cells typically derived from bone marrow, adipose (fat) tissue, or umbilical cord blood. They are known for their strong anti-inflammatory properties and their ability to promote tissue repair and angiogenesis, making them ideal for regenerating ovarian tissue. SVF, on the other hand, is a heterogeneous cell mixture extracted from adipose tissue and contains not only stem cells but also immune cells, endothelial cells, and growth factors. While SVF provides a broader cellular environment that may enhance regeneration, MSCs offer a more targeted and controlled approach. Both types show promise in improving ovarian function in patients with poor response to IVF, but their mechanisms and clinical outcomes may vary depending on the patient’s condition and the protocol used.

Evidence on Egg Count and Embryo Quality Improvement

Clinical studies investigating stem cell therapy for poor ovarian response have shown encouraging results in terms of egg count and embryo quality. Patients receiving stem cell injections, particularly with mesenchymal stem cells or stromal vascular fraction, have demonstrated increased follicle development and higher numbers of retrievable eggs during IVF cycles. Additionally, improvements in embryo quality have been reported, likely due to the enhanced ovarian microenvironment and improved blood flow stimulated by the regenerative properties of stem cells. While these findings are promising, it is important to note that research is still ongoing, and larger, controlled trials are needed to confirm long-term safety and efficacy. Nonetheless, current evidence supports the potential of stem cell therapies as a valuable adjunct in fertility treatment for women facing diminished ovarian reserve or poor response.

Treatment Journey: Injection Process to Monitoring

The treatment journey for stem cell therapy in poor ovarian response typically begins with a thorough evaluation by a fertility specialist to determine eligibility and tailor the protocol. The stem cells—either mesenchymal stem cells or stromal vascular fraction—are usually harvested from the patient’s own adipose tissue or bone marrow through a minimally invasive procedure. After preparation, the stem cells are injected directly into the ovaries under ultrasound guidance to maximize precision and safety. Following the injection, patients enter a monitoring phase where ovarian function is closely tracked through hormonal tests and ultrasound scans to assess follicle growth and response. This period allows doctors to determine the optimal timing for ovarian stimulation and egg retrieval during IVF. Throughout the process, patients receive supportive care and counseling to manage expectations and address any concerns. The combination of personalized treatment and careful monitoring aims to enhance ovarian rejuvenation and improve overall IVF outcomes.