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Stromal Vascular Fraction (SVF)

Mechanical SVF (Stromal Vascular Fraction) is a cocktail containing mesenchymal stem cells among other components such as precursor cells of fat cells, fibroblasts, precursor cells of endothelium, endothelial cells, and predominantly stromal cells, rich in growth factors. Stromal cells repair tissues and facilitate regeneration when there is damage caused by both internal and external factors like injury, disease, or aging. Stromal cells extracted from adipose tissue via liposuction are separated while maintaining their viability. These cells are centrifuged using a smartfuge to obtain the cellular product, Mechanical SVF.

Alternative for Patients Unwilling to Undergo Surgery

Mechanical SVF therapy is used in orthopedics for early-stage cartilage damage in patients with painful joints who are either not yet suitable for surgical treatment or unwilling to undergo surgery, aiming to halt the progression of cartilage damage and support its healing. The goal of Mechanical SVF therapy is to delay the patient’s prosthetic process and improve their quality of life.

Where is Mechanical SVF Used?

  • Osteoarthritis
  • Joint injuries
  • Tendon injuries
  • Sports injuries
 Mechanical SVF therapy provides an alternative solution for conditions like avascular necrosis. Regenerative cells isolated from adipose tissue are concentrated by centrifugation and then applied intra-articularly with ultrasound guidance in the same session. As cartilage tissue forms, the joint heals and begins to function.

How is SVF Obtained?

The system used for SVF application is a CE, FDA, KFDA, TGA certified ultra-sharp blade system that can quickly and easily process fat tissue obtained simply and easily from your patients. Through this closed and sterile system, live fat tissue is isolated to obtain Mechanical SVF containing regenerative cells. With ultra-sharp blades in the smart kit, strong connections between parenchymal and stromal cells in fat tissue are cut without applying blunt pressure. This ensures the stromal cells are separated while maintaining their viability. The separated cells from the fat tissue are centrifuged using a smartfuge to obtain Mechanical SVF, a cellular product.

Effective, Easy, Safe

  • Stromal cell isolation is achieved without blunt pressure.
  • Cell viability reaches up to 99%.
  • High cell numbers are achieved.

In Which Other Clinical Applications is SVF Used?

  • Cosmetic surgery: SVF derived from fat tissue can be used for volume augmentation and filling purposes for the face and body.
  • Treatment of traumatic wounds: SVF can be used for tissue healing and rapid recovery.
  • Orthopedic surgery: SVF can be used for the treatment of joint disorders. For example, it can be used in osteoarthritis therapy.
  • Diabetic wound treatment: SVF can be used in diabetic wound healing.
  • Dermocosmetics: SVF can be used for rejuvenation, beautification, and volumizing the skin.
  • Regenerative Medicine: SVF can be used for organ and tissue regeneration.

Volume Renewal in 4 Steps

  • Autologous Fat Collection
A special designed fat collection cannula and negative pressure provided by a snapper in the smart kit ensures safe autologous fat collection under sterile conditions. 
  • Mechanical Separation in a Closed Sterile System
Fat tissue obtained from the patient is successively passed through the 2,400µ, 1,200µ, 600µ, and 400µ blades between two syringes after the initial centrifugation. The cutting process separates the parenchymal cells from the fat tissue’s stromal cells. 
  • Mechanical SVF Injection
Mechanical SVF cell cocktail ensures regeneration in cartilage and connective tissue, starting the repair of the damaged joint functions, and enhancing the patient’s quality of life. 
  • SVF Isolation with Smartfuge
After separation, the fat tissue is centrifuged at 1200 G for 5 minutes in the Smartfuge, yielding Mechanical SVF with up to 99% live cells. Designed to prevent vibration, the Smartfuge quickly reaches the desired rotational speed with a 90° radius, distributing internal pressure evenly.