Mesenchymal Stem Cell?
Mesenchymal Stem Cells (MSC) are versatile adult stem cells found in our body. They are typically found in bone marrow, adipose tissue, and other tissues and can differentiate into different cell types when activated by growth factors and other signals.
What is Mesenchymal Stem Cell?
Mesenchymal stem cells (MSCs) are the primary cells found in connective tissue. MSCs have the ability to migrate from the tissues they inhabit in the body to damaged tissues and possess the capability to differentiate in various environments. They are multipotent cells that contribute to the repair of most tissues and organs, remaining undifferentiated, self-renewing, and regulating the immune system.
Characteristics of Mesenchymal Stem Cells:
They have the potential to correct enzyme defects in genetic diseases by enabling the production of enzymes.
- They can be isolated from various tissue types and can be expanded in vitro.
- They possess immunomodulatory effects.
- They have immunosuppressive effects.
- They can be applied alloge-nically without eliciting immune rejection.
- Due to their ease of gene transfer and resilience, they are suitable for gene therapy.
- They are cells capable of differentiating into various tissues.
- They have the potential for differentiation (transdifferentiation) into cell types such as neurons, hepatocytes, and pancreatic cells.
- In addition to repairing damages in their native environment, they can migrate to damaged areas in other tissues to aid in repair.
- Due to their immunosuppressive/non-immunogenic properties, they do not stimulate the immune system.
Sources of MSCs:
Although there are many sources of mesenchymal stem cells in the body, the StemBio Cord Blood, Cell, and Tissue Center uses the following sources for MSCs:
- Mesenchymal Stem Cells from Bone Marrow.
- Mesenchymal Stem Cells from Synovial Tissue.
- Mesenchymal Stem Cells from Adipose Tissue.
Mesenchymal Stem Cells are found in various tissues in the body, including bone marrow, umbilical cord, adipose tissue, dental pulp, placenta, and amniotic fluid. Mesenchymal Stem Cells derived from adipose tissue, bone marrow, and umbilical cord are cultured in our laboratories that adhere to Good Manufacturing Practice (GMP) standards, passing through quality control analyses to be prepared for application to patients. Due to their potent regenerative effects, capacity for neovascularization, and immune-regulating/suppressive effects, they have a wide range of applications.
- Mesenchymal Stem Cells from Cord Matrix.
Clinical Uses of Mesenchymal Stem Cells
MSCs are used in treating diseases resulting from damage to tissues and organs derived from mesenchymal cells such as bone, cartilage, muscle, and adipose tissue.Due to their strong immunosuppressive effects, they are used in the prophylaxis and treatment of acute Graft versus Host Disease (GVHD) following allogeneic stem cell transplants.
They are utilized in soft tissue defects, non-healing chronic wounds (such as diabetic ulcers), treatment of burn scars, peripheral vascular diseases (such as Buerger’s disease, ischemic foot), tissue damage surrounding the removal of a tumor (such as post-mastectomy breast reconstruction), facial fillers, hand and facial rejuvenation (wrinkle reduction) procedures.
- Clinical research studies indicate their potential use in treating autoimmune diseases such as Autoimmune Encephalomyelitis, Osteogenesis Imperfecta, Rheumatoid Arthritis, Crohn’s Disease, Systemic Lupus, Type I Diabetes, and Multiple Sclerosis.
How is Mesenchymal Stem Cell Therapy Administered?
The production and application of mesenchymal stem cells derived from bone marrow and adipose tissue are performed autologously, specifically for the individual. Meanwhile, those derived from umbilical cord tissue are produced and applied allogenically (from a donor). For the production of individual-specific mesenchymal stem cells, upon the physician’s request, a biopsy of bone marrow and/or adipose tissue is required from the patient. Alongside the biopsy, blood is drawn from the individual and sent under special transfer conditions to laboratories. In the laboratory, mesenchymal stem cells are cultured in the individual’s serum obtained from their own blood. If the necessary quality control tests are successful, the required number of mesenchymal stem cells requested by the physician for the specific area of application and damage are prepared and transferred for application. It is necessary to administer the transferred cells within 48 hours.