PGT & Embryo Selection: How Preimplantation Genetic Testing Improves Outcomes

In the world of assisted reproduction, choosing the right embryo can significantly influence IVF success rates. Preimplantation Genetic Testing (PGT) has emerged as a powerful tool to improve these outcomes by identifying chromosomally normal and genetically healthy embryos before transfer. By screening embryos for specific genetic abnormalities or aneuploidies, PGT helps reduce the risk of miscarriage, increases the chance of implantation, and can shorten the time to pregnancy. For couples facing infertility, recurrent pregnancy loss, or known genetic conditions, PGT provides an added layer of precision—helping fertility specialists make informed decisions and giving intended parents greater confidence in their journey toward building a healthy family.

Understanding PGT-A and PGT-M: Which Genetic Tests Are Best for You?

Preimplantation Genetic Testing comes in different forms, with PGT-A (for aneuploidy) and PGT-M (for monogenic disorders) serving distinct but equally valuable purposes. PGT-A is designed to detect chromosomal abnormalities—such as missing or extra chromosomes—that may lead to implantation failure, miscarriage, or conditions like Down syndrome. This test is commonly recommended for women over 35, individuals with recurrent pregnancy loss, or couples undergoing multiple IVF cycles. On the other hand, PGT-M is used when one or both partners carry a known genetic mutation that could be passed on to their child, such as cystic fibrosis or Tay-Sachs disease. Choosing the right test depends on your family history, age, and fertility background. A thorough consultation with a fertility specialist and genetic counselor can help determine which testing route aligns best with your goals and risks, ultimately guiding you toward the healthiest possible pregnancy outcome.

Preventing Genetic Disorders Before Transfer—At the Embryo Stage

One of the most significant advancements in IVF technology is the ability to screen embryos for genetic disorders before transfer, offering hope to couples at risk of passing on inherited conditions. Through techniques like Preimplantation Genetic Testing (PGT), embryos can be analyzed at the cellular level to detect mutations or chromosomal abnormalities early on. This proactive approach allows fertility specialists to select embryos free from specific genetic diseases, significantly reducing the likelihood of affected pregnancies and improving overall IVF success rates. By preventing genetic disorders at the embryo stage, families can move forward with greater confidence and peace of mind, knowing they are giving their future child the healthiest possible start.

Pricing, Timeline and Accuracy of PGT Services at Dr. Invitro

At Dr. Invitro, the pricing for Preimplantation Genetic Testing (PGT) varies depending on the type of test—PGT-A (for chromosomal abnormalities) or PGT-M (for specific genetic disorders)—and the number of embryos analyzed. Typically, the entire process takes about 6 to 8 weeks, encompassing ovarian stimulation, egg retrieval, embryo biopsy, genetic analysis, and embryo freezing. Results from the genetic tests are usually available within 7 to 14 days after the biopsy, followed by scheduling a frozen embryo transfer (FET). While PGT provides highly valuable insights and significantly improves IVF outcomes, it is important to note that no test is 100% error-free. The biopsy involves taking a small sample of cells, and although rare, there is a slight risk of damaging the embryo. Additionally, false positives or negatives may occur, so comprehensive counseling and careful interpretation of results are essential. Patients considering PGT at Dr. Invitro are encouraged to discuss the costs, timeline, and potential risks thoroughly with their care team to make informed decisions tailored to their unique situation.