NEXT-GENERATION SEQUENCING (NGS)

Next-Generation Sequencing or NGS is a new technology for comprehensive chromosome testing of IVF embryos.

    NEXT-GENERATION SEQUENCING (NGS)

    Next-Generation Sequencing or NGS is a new technology for comprehensive chromosome testing of IVF embryos.

    We now know that many normal-appearing embryos have abnormalities in the number of chromosomes (aneuploidy). These abnormalities are the leading cause of IVF implantation failure and spontaneous miscarriage. Based on these facts, studies were performed to try to identify and exclude from transfer those embryos with chromosomal abnormalities. This type of testing is known as preimplantation genetic screening or PGS. Next-Generation Sequencing uses for screening embryos for chromosome abnormalities. Next-generation sequencing (NGS) permits the simultaneous interrogation of multiple disease-causing variants in many genes, for selecting genetically normal embryos.   

    Advantages of NGS:

    •   Reduced cost
    •   Enhanced detection of structural abnormalities such as chromosomes with missing or duplicate segments
    •   Better ability to detect when an embryo may have cells with differing results (mosaicism)
    •   Reduction of human errors by the increasing use of automation

    When do we recommend NGS?

    • Female age over 40
    • Repeated pregnancy loss
    • Repeated IVF treatment failure
    • Severe male infertility

    NGS is performed in our IVF Clinic with high success rates.

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