• Blloku, Rruga Donika Kastrioti 3, Tiranë, Albania
  • +355 69 707 0070
  • ivf@ith.al


Natural Cycle IVF or modified natural cycle is an amazing option for women with low egg reserve or low responder patients with the classical medication protocols.

Advantage of the Natural IVF Cycle

Natural Cycle IVF or modified natural cycle is an amazing option for women with low egg reserve or low responder patients with the classical medication protocols. This treatment option aims to recruit naturally developed follicule and collect less egg cells but maturated by itself. 

Dr.Invitro has tremendious experience and expertise in both Natural Cycle IVF and controlled ovarien stimulation protocols in Albania. We are able to apply  new protocols and methods to advance in our clinic and to increase its success rates for all groups of patients.

As is expected,  Natural IVF cycle and Modified Natural IVF cycle  treatments are recommended to women with low egg reserve or low responder patient, the success rates might be lower per cycle.  But in this group of patienst the Cumulative success rate after several cycles of treatment may be significantly higher. Avoiding use of high dose medication, this methods give to a patient the chance to try with her own eggs before consider to the option  to use donor eggs.

During Natural Cycle IVF folow up mostly medication which stimulates follicule groth doesn’t necessary. Follicular development follows with transvaginal ultrasound, and every follicular and endometrial changins notes by the physician and determine to time of egg collection. After egg collection procedure, other steps of treatmens continoues same in normal COH protocols.

Who is suitable for Natural IVF Cycle and Modified NaturaIVF Cycle

  • POF( Premature Ovarian Failure Patient)
  • Patient  who have had a poor or low response  to controlled ovarian-stimulation IVF (e.g. produced fewer than three eggs)
  • Patients who wants to avoid the risks and side effects of high-dose stimulation IVF
  • Women who are older ages and low ovarian reserve but wish to try with their own eggs.
  • Women who have a history of hormone-dependent cancers.

The conventional controoled ovarien -stimulation (COH) IVF protocols generally use medications to stimulate  the ovaries to develop many follicules. In contrast Natural Cycle IVF does not need to stimulate follicule recruitment, it is focused on collecting the one follicle naturally selected by the body. 

Some of medical researchs suugests, eggs that are naturally selected by the body can be of higher quality than those produced in a stimulated IVF cycle. Some of medical researchs put forward the quality of egg is same but patient compliance is better and side effect and emotional burden are lower than conventional protocols.

Potential side effects of conventional Controlled ovarien Hyperstimulation

  • Hot flushes
  • Mood swings (such as feeling down or irritable) 
  • Headaches/migraines
  • Fatigue
  • Risk of Thromboembolism
  • Risk of developing Ovarian Hyperstimulation Syndrome (OHSS)
  • Abdominal bloating and swelling

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What's the difference between conventional high stimulation IVF & Natural IVF?

In conventional high-stimulation IVF, medications are given in the form of daily injections up to stimulation protocol (!0-21 days). In Natural IVF Cycle mostly does not need medication for stimulation. In well selected patient group pregnancy chance, success rate of treatment are same. 

In some COH cycle because of alteration of hormone balance in women endometrial reseptivity and implantation may be effected adverselly. In Natural IVF cycle endometrial changings generally occures more naturally.